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Antioxidant Defense: Vitamin C and botanical extracts protect against future discoloration caused by friction, UV rays, or aging

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the rest is mechanistic reasoning that a clinician should weigh individually: Known copper or peptide allergy the most concrete contraindication, explicit enough that clinical researchers screen it out (NCT07437586)

Applying degraded GHK-Cu delivers free copper ions and amino acid breakdown products instead of the active peptide complex at best, this produces zero collagen synthesis or wound healing benefit, and at worst, free copper can act as a pro-oxidant generating reactive oxygen species that cause irritation, redness, or hyperpigmentation